Pathologic Findings and Toxin Identification in Cyanobacterial (Nodularia spumigena) Intoxication in a Dog

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Nodularia spumigena

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Occurrence of the hepatotoxic cyanobacterium Nodularia spumigena in the Baltic Sea and structure of the toxin.

Water blooms formed by potentially toxic species of cyanobacteria are a common phenomenon in the Baltic Sea in late summer. Twenty-five cyanobacterial bloom samples were collected from open and coastal waters of the Baltic Sea during 1985 to 1987, and their toxicity was determined by mouse bioassay. All of 5 bloom samples from the southern Baltic Sea, 6 of 6 from the open northern Baltic Sea (G...

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Atypical bromethalin intoxication in a dog: pathologic features and identification of an isomeric breakdown product

BACKGROUND Definitive post mortem confirmation of intoxication by the neurotoxic rodenticide bromethalin can be challenging. Brain lesions are not specific and detection of bromethalin and its metabolites are unpredictable due to rapid photodegradation and inconsistent behavior in tissues. CASE PRESENTATION A 2-year-old dog presented with rapid onset of severe muscle tremors and death within ...

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Nodularia spumigena Peptides—Accumulation and Effect on Aquatic Invertebrates

Thus far, the negative effects of Nodularia spumigena blooms on aquatic organisms have been mainly attributed to the production of the hepatotoxic nodularin (NOD). In the current work, the accumulation of other N. spumigena metabolites in blue mussels and crustaceans, and their effect on Thamnocephalus platyurus and Artemia franciscana, were examined. The liquid chromatography-tandem mass spect...

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Histopathological changes in liver and gill of Acipenser persicus fry in short term exposure to Nodularia spumigena

Persian sturgeon, Acipenser persicus is a native, commercially important and highly steemed fish species in the Caspian Sea. In this study, effects of Nodularin (NODLN), a cyclic pentapeptide hepatotoxin, on liver and gill tissues of A. persicus were studied. Nodularin was produced in high amounts by Nodularia spumigena, a cyanobacterium species during the algal bloom in the Caspian Sea an...

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ژورنال

عنوان ژورنال: Veterinary Pathology

سال: 2011

ISSN: 0300-9858,1544-2217

DOI: 10.1177/0300985811415703